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The Guthrie's returned to North America in 1934 when Betty was five years old. In Toronto, his wife enrolled Betty in a kindergarten class. The teacher believed that one of the children had metabolic disorders. Guthrie was offered the job of a bottle-feeding assistant on account of his medical background. After a few days, the teacher came to the parents and asked if Guthrie was willing to look after the baby. The parents agreed that Betty should be treated. Guthrie then phoned his brother, Professor Dr. Robert Guthrie, who told him that his daughter had PKU and to get her tested. Although Guthrie had no training in neonatal diseases, he managed to secure a job with a well-known hospital in Toronto. Betty was put on a low-Phe diet. Guthrie also enrolled in McMaster University Medical School. His studies were interrupted because of World War II. After the war, he worked at McMaster. He became a Professor and the Department of Pediatrics was established. Guthrie decided to return to Toronto. In his spare time, Guthrie continued to work at the Hospital and his weekly trips to the laboratory became more frequent. As Guthrie and his wife were in their late thirties, they decided to adopt an infant. They went to a 'high risk' clinic and were told that the infant might have a genetic disorder that would kill him or his wife if it was not treated. Guthrie drove to the nearest Phe-free clinic where the infant, later named David, was born.
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